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What are the effects of nanosilver on the body

wallpapers News 2021-01-08
Silver is an ancient antibacterial material. About a thousand years ago, Mongolian herders knew that using silver utensils to hold horse's milk would make the horse's milk degenerate. The antibacterial effect of silver mainly comes from the adsorption of silver ions to microorganisms. When microorganisms are adsorbed by silver ions, their respiration enzymes will die after being destroyed.
Under nanotechnology, the size of silver ions becomes very small, so it can easily pass through the human barrier of the skin and mucous membranes, circulate through the blood, and reach other organs and parts of the human body. Studies have shown that it can damage liver cells and nerve cells. When a large number of silver ions are deposited in the human body, it will have an irreversible impact on the human body.
We often see various deodorant socks, cups, underwear, gynecological products, electrical appliances, etc., featuring nano-silver materials on e-commerce platforms. Don’t be fooled by the "high-tech" banner of nano-silver. The potential hazards of silver as heavy metal and The super permeability of nano-sized particles is bound to be harmful to the human body.
The impact of nano silver on the body and the environment
Effects on the skin
Nano silver particles can penetrate intact skin into the dermis. When tested on damaged skin, the penetration ability of nano silver particles is increased by nearly 5 times. These nanoparticles that enter the dermis can be transferred to the lymph nodes in the area and eventually enter the blood circulation and other tissues and organs.
In vitro experiments have found that the toxicity of nano-silver to fibroblasts is much higher than its toxicity to plasma cells. The pigs were damaged by skin damage, inoculated with various pathogens, and treated with nano-silver-containing dressings. The results showed that compared with the blank control and the silver nitrate control group, the metalloproteinase activity of the nano-silver treatment group was reduced and cell apoptosis was induced.
Effects on the respiratory system
The deposition and clearance rate of nanoparticles in the respiratory system affect the degree of respiratory system damage.
Although nano-silver did not cause obvious organ toxicity to rats after 28 days, the tissue distribution showed that the silver content in the lungs increased significantly, and the liver, brain tissue and olfactory bulb showed a significant dose-responsive increase in tubes and alveoli.
Due to the small size of metal nanoparticles, they have a high diffusion capacity in the air, so they are easily deposited in various parts of the respiratory system (nasopharynx, bronchi, alveoli).
Effects on the immune system
Nano silver can often be used as an immunomodulator to promote wound healing and treat immunogenic skin diseases. The mechanism may be that Ag ten binds to metallothionein and inhibits inflammatory cytokines such as IL12 and TNFa. Gameretal. reported that nano-silver colloids coated with citric acid caused massive consumption of glutathione in red blood cells, resulting in oxidative damage. Inject 0.2ml of 10mg/L nano silver particle solution at different stages of chicken embryo development. Histopathology and laser confocal microscopy showed that the chicken embryo’s bursa was significantly damaged, which significantly reduced the number and size of lymphoid follicles. Bursa of Fabricius is the primary place for lymphatic B cell migration and proliferation. The destruction of the bursa of Fabricius by nano-silver means an adverse effect on the immune system (function).
Effects on the nervous system
Nano silver can pass through the blood-brain barrier and enter astrocytes, causing neuronal degeneration.
Experiments have found that after nano-silver is implanted into BALB/C mice or Wistar rats, the nano-silver can pass through the blood-brain barrier with the blood, and over time, the accumulation of silver increases.
Through histochemical auto-imaging technology, it is confirmed that nano-silver can be deposited in the cerebral ventricle, arachnoid membrane, into glial cells and neuronal cells, providing a theoretical basis for the neurotoxicity study of nano-silver.
According to a case report, in a four-month study of a 71-year-old man, oral colloidal silver daily can lead to increased levels of silver in human plasma, red blood cells and the central nervous system. Eventually, he developed seizures and coma and died 5.5 months later. Therefore, it is believed that silver can cause irreversible neurotoxic damage and eventually cause death.